Mitogen-activated protein kinase kinase kinase 8
Cot belongs to the STE Ser/Thr protein kinase family. It is shown to mediate phosphorylation of histone H3 at Serine 10 position on the c-fos promoter that contributes to its transcriptional regulation ultimately affecting cellular transformations (PMID: 17724252).
| UniprotKB Accession | P41279 |
|---|---|
| Alternative Name(s) | Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 (TPL-2) |
| Writer for PTM/s | H3S10ph |
| EC number | 2.7.11.25 |
| No. of coding genes | Mitogen-activated protein kinase kinase kinase 8 is coded by following 1 non-allelic gene/s |
| Gene name | mitogen-activated protein kinase kinase kinase 8 |
| Gene symbol | MAP3K8 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | COT, ESTF |
| Aliases | Tpl-2, EST, c-COT, MEKK8 |
| GeneID | 1326 |
| Chromosomal location | 10p11.2 |
| HGNC | 6860 |
| Unigene | Hs.432453 |
| MIM | 191195 |
| RefSeq mRNA | |
| RefSeq Protein | |
| Disease associations | No disease associations known for Mitogen-activated protein kinase kinase kinase 8 |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2